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Evading the plant immune system by intrinsic disorder

MarĂ­n et al., 2013, The Plant Cell, Ott lab

15.08.2013

Intrinsic Disorder in Pathogen Effectors: Protein Flexibility as an Evolutionary Hallmark in a Molecular Arms Race

Macarena Marín, Vladimir N. Uversky and Thomas Ott

130814_id_effectorsA central paradigm of structural biology is that protein function depends on a fixed three-dimensional structure. This has been defied by the discovery of intrinsically disordered proteins, which lack a defined structure. Based on in silico proteome-wide surveys we discuss how disorder may contribute to function and evolution of effectors in the molecular arms race between hosts and pathogens.